Transposagen is developing several inbred and outbred rat stem cell lines for the creation of TKO™ Knockout Rat Models. The company has exclusive rights to rat spermatagonial stem cells, which offer significant advantages over rat embryonic stem cells and rat induced pluripotent stem cells in terms of speed and efficiency that a knockout animal can be created.
Transposagen’s off the shelf TKO® and TGEM® rat models cover a range of disease and research applications. We have partnered with world experts in over 40 collaborations worldwide in order to validate and characterize our genetically engineered rat models. We have approximately 300 off-the-shelf models which is the world’s largest commercially available collection. Our characterized genetically engineered models are broken down into the research categories below.
Drug Metabolism
Immune System
Neuroscience –CNS
Metabolic Disease/Obesity
Cardiovascular
Cancer/Toxicology
Some models have not been characterized and are available either in colony or cryopreserved. Please search the database for availability of the lines.
TKO™ Knockout Rat Models - Laboratory rats with a single gene trap insertion created using mobile DNA technology. Detailed TKO™ Knockout Rat Model Database
TGEM™ Rat Models - Laboratory rats with a genetic mutation not created by a gene trap insertion. Detailed TGEM™ Rat Model Database